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Summary:The White House, under Donald Trump, has issued a directive to AstraZeneca and all drug manufacturers to implement Most-Favored-Nation (MFN) drug pricing for American patients, aiming to stop other nations from "freeloading" on American innovation and to lower prescription drug costs significantly by September 29, 2025.
Sentiment:Directive/Demanding
Key Claims:
  • Americans currently pay up to three times more for identical prescription drugs than patients in other developed nations.
  • Other nations are "freeloading" on American innovation in drug development.
  • An Executive Order on "Most-Favored-Nation Prescription Drug Pricing" was signed on May 12, 2025.
  • Drug manufacturers are called upon to extend MFN pricing to Medicaid, guarantee MFN pricing for newly-launched drugs, return increased revenues from abroad to American patients, and offer direct purchasing at MFN prices.
  • The Administration is prepared to use every tool to protect Americans from abusive drug pricing practices if cooperation is not met.
  • Binding commitments for these goals are expected by September 29, 2025.
Potential Market Impact (S&P 500):8/10
Potential Geopolitical Risk:0/10
Potential Global Cross-Asset Impact:7/10